Research of antimicrobial efficacy of modern antiseptic agents based on decamethoxine and povidone-iodine
Under conditions of wide increased resistance of pathogens of infectious complications to antimicrobial agents, a considerable attention is paid to the use of antiseptic drugs. The research of their antimicrobial efficacy remains valid for substantiation of the rational use. The purpose was to carry out a comparative study of the antimicrobial efficacy of medicinal antiseptic agents based on decamethoxine and povidone-iodine.
In the study there was examined antimicrobial activity of mentioned antiseptics against 682 clinical strains of microorganisms (A. baumannii, S. aureus, P. aeruginosa, Enterococcus spp., E. coli, Enterobacter spp., K. pneumoniae, Proteus spp.), isolated from patients with infectious complications. Minimum inhibitory and bactericidal concentrations of 1–2– 10 % iodine, 0.02 % decamethoxine (decasan) were determined. Antimicrobial efficacy of medicines, based on studied antiseptics was evaluated with the use of an index of antiseptic activity, calculated by means of commonly used methods.
The study revealed high bactericidal properties of decasan against clinical strains of S. aureus, Enterococcus spp., E. coli, K. pneumoniae and Enterobacter spp. The advantages of antimicrobial activity of decamethoxine-based antseptis (decasan, p < 0.001) were proved. Iodine has expressed antimicrobial properties against Enterococcus spp., S. aureus, A. baumannii, bacteria of the Enterobacteriаcеae family and P. aeruginosa. It is proven that the dissolution of povidone-iodine leads to the reduction of the antimicrobial efficacy of 2 % antiseptic solution. There was found inefficacy of 1 % povidone-iodine against infectious agents (p < 0.001).
Thus, the leading Gram-positive (S. aureus, Enterococci) and Gram-negative pathogens (Escherichia, Klebsiella, Enterobacteria, Acinetobacteria, Pseudomonas) have a sensitivity to iodine and to domestic preparation based on decamethoxin 0.02 % (decasan), with a definite advantage of the antimicrobial properties of the latter to Gram-positive and some Gram-negative microorganisms (p < 0.001).
WHO (2014). Antimicrobial resistance: global report on surveillance 2014. [online] WHO. Available at: https://www.who.int/iris/bitstream/10665/112642/1/9789241564748_eng.pdf
Magiorakos A-P, Srinivasan A, Carey RB, Carmeli Y, Falagas ME, Giske CG, et al. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clinical Microbiology and Infection [Internet]. Elsevier BV; 2012 Mar;18(3):268–81. Available from: https://doi.org/10.1111/j.1469-0691.2011.03570.x
Ayisi LA, Adu-Sarkodie Y. Extended-spectrum-beta-lactamase (ESBL) production among Escherichia coli and Klebsiella species in Kumasi, Ghana. J Nat Sci Res. 2015; 5:81- 6.
Nazarchuk OA. Microbiological and molecular research of the resistance in gram-negative pathogens of infectious complications to carbapenem antibiotics, approaches to its combating. Moldovan Journal of Health Sciences. 2017; 13 (3): 22-32.
Andreieva ID, Osolodchenko TP, Riabova IS, Zavada NP, Batrak OA, Lukianenko TV. Otsinka antybiotykorezystentnosti uropatoheniv pry infektsiiakh sechovykh ta statevykh shliakhiv (Evaluation of antibiotic resistance of uropathogens in urinary and genital tract infections). Achievements of clinical and experimental medicine [Internet]. Ternopil State Medical University; 2015 Jun 5;22(1). Available from: https://doi.org/10.11603/1811-2471.2015.v22.i1.4241
Palii HK., Nazarchuk OA, Honchar OO, Nazarchuk HH, Zaderei NV, Oliinyk DP, ta in. Formuvannia rezystentnosti u shtamiv stafilokokiv do likarskykh antyseptychnykh preparativ (Formation of resistance to strains of staphylococci to medical antiseptic drugs). Visnyk morfolohii. 2013; 19 (2) : 286 - 289. (In Ukrainian)
Wisplinghoff H, Schmitt R, Wöhrmann A, Stefanik D, Seifert H. Resistance to disinfectants in epidemiologically defined clinical isolates of Acinetobacter baumannii. Journal of Hospital Infection [Internet]. Elsevier BV; 2007 Jun;66(2):174–81. Available from: https://doi.org/10.1016/j.jhin.2007.02.016
WHO Global Strategy for Containment of Antimicrobial Resistance, http://www.who.int/drugresistance/WHO_Global_Strategy_English.pdf.
Allegranzi B, Bischoff P, de Jonge S, Kubilay NZ, Zayed B, Gomes SM, et al. New WHO recommendations on preoperative measures for surgical site infection prevention: an evidence-based global perspective. The Lancet Infectious Diseases [Internet]. Elsevier BV; 2016 Dec;16(12):e276–e287. Available from: https://doi.org/10.1016/s1473-3099(16)30398-x
Palii HK, Kovalchuk VP, Fomina NS. Kharakterystyka suchasnoho arsenalu dezinfektsiinykh zasobiv ta problemy dezinfektolohii (Characteristics of the modern arsenal of disinfectants and problems of disinfectology). Biomedical and Biosocial Anthropology. 2014; 22 : 82-85. (In Ukrainian)
European Centre for Disease Prevention and Control. Surveillance of surgical site infections in Europe 2010–2011 [Internet]. Stockholm: ECDC. 2013 Oct[cited 2018 Aug30]. Available from: https://ecdc.europa.eu/sites/portal/files/media/en/publications/Publications/SSI-in-europe-2010-2011.pdf
World Health Organization. Global Guidelines for the Prevention of Surgical Site Infection [Internet]. Geneva, Switzerland: WHO. 2016. San Francisco: Matthew Holt. 2003 Oct [cited 2018 Aug 30]. Available from: http://apps.who.int/iris/bitstream/handle/10665/250680/9789241549882-eng.pdf;jsessionid=1F8A9546C46F1803027E22A3F82DBEE4?sequence=1
Kompendium. Likarski zasoby (Compendium. Medicines ). MORION; 2019. (In Ukrainian) Available from: https://compendium.com.ua/uk/akt/80/2864/povidonumiodum/
Vyznachennia chutlyvosti mikroorhanizmiv do antybakterialnykh preparativ (Determination of the sensitivity of microorganisms to antibacterial drugs): Order, Directions on April 5, 2007 № 167. Ministry of Healthcare. (In Ukrainian) Available from:: http://mozdocs.kiev.ua/view.php?id=6958
Krasylnykov, AP. Spravochnyk po antyseptyke (Antiseptic Guide). Minsk: Visheishaia shkola; 1995. 470 p. (In Russian)
Potapov VYu, Vakulenko EN, Protasenko YaD. Vyibor optimalnyih antisepticheskih sredstv dlya obrabotki kostnoy polosti v protsesse hirurgicheskogo lecheniya nagnoivshihsya radikulyarnyih kist (Selection of optimal antiseptics for the treatment of the bone cavity during the surgical treatment of suppurative radicular cysts). Ukrainian Dental Almanac. 2016; 4 : 40-42. (In Russian)
Mama M, Abdissa A, Sewunet T. Antimicrobial susceptibility pattern of bacterial isolates from wound infection and their sensitivity to alternative topical agents at Jimma University Specialized Hospital, South-West Ethiopia. Annals of Clinical Microbiology and Antimicrobials [Internet]. Springer Nature; 2014;13(1):14. Available from: https://doi.org/10.1186/1476-0711-13-14
Saperkin N, Kovalishena O, Blagonravova A. P089: Surveillance of bacterial resistance to disinfectants. Antimicrobial Resistance and Infection Control [Internet]. Springer Nature; 2013 Jun;2(S1). Available from: https://doi.org/10.1186/2047-2994-2-s1-p89
Gerba CP. Quaternary Ammonium Biocides: Efficacy in Application. Müller V, editor. Applied and Environmental Microbiology [Internet]. American Society for Microbiology; 2014 Oct 31;81(2):464–9. Available from: https://doi.org/10.1128/aem.02633-14
Palii HK, Pavliuk SV, Palii DV, Nazarchuk OA, Dudar AO. Obgruntuvannia zastosuvannia antyseptychnykh preparativ v systemi profilaktychnykh i likuvalnykh zakhodiv (Substantiation of the use of antiseptic drugs in the system of preventive and therapeutic measures). Bukovinian Medical Herald. 2018; 22 (4) : 51-56. (In Ukrainian)
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