Perioperative antibiotic prophylaxis in surgery

Authors

  • Dmytro Dmytriiev National Pirogov Memorial Medical University, Vinnytsia
  • Oleksandr Nazarchuk National Pirogov Memorial Medical University, Vinnytsia
  • Yuliana Babina National Pirogov Memorial Medical University, Vinnytsia

DOI:

https://doi.org/10.31636/prmd.v4i1.2

Keywords:

antibiotic prophylaxis, cephalosporins, cefoperazone, sulbactam, Laxers

Abstract

Infectious complications in surgery occupy a significant place among the causes of death and increase in the cost of medical care for various pathologies. Antibiotic prophylaxis takes one of the first places in the perioperative period, in addition to surgical treatment and compliance with the rules of asepsis and antiseptics. Laxers is a new drug in the cephalosporin group, consisting of a combination of cefoperazone and sulbactam. It has a wide range of action on gram(-) and anaerobic flora and antistaphylococcal activity, which is not inferior to cefoperazone. Due to sulbactam, it has antimicrobial activity against Pseudomonas aeruginosa and Acinetobacter spp. This article describes the main properties and advantages of Laxers over other cephalosporins in this group as the drug of choice in the treatment of surgical pathologies and alternative antibiotic prophylaxis in the perioperative period in severe patients at risk of contamination of the operating field with hospital flora.

Downloads

Download data is not yet available.

References

Epidemiological surveillance of infections in the field of surgery and their prevention. Available from: https://zakon.rada.gov.ua/rada/show/v0181282-08

Yakovlev SV. High-tech perioperative antibiotic prophylaxis in the context of the Fast Track surgical concept [Vysokotekhnologichnaya perioperacionnaya antibiotikoprofilaktika v kontekste hirurgicheskoj koncepcii Fast Track]. Doctor RU; 2016;12-1:43-48. [In Russian]

Bratzler DW, Houck PM. Antimicrobial prophylaxis for surgery: An advisory statement from the National Surgical Infection Prevention Project. The American Journal of Surgery [Internet]. Elsevier BV; 2005 Apr;189(4):395–404. Available from: https://doi.org/10.1016/j.amjsurg.2005.01.015

Bratzler DW, Dellinger EP, Olsen KM, Perl TM, Auwaerter PG, Bolon MK, et al. Clinical practice guidelines for antimicrobial prophylaxis in surgery. American Journal of Health-System Pharmacy [Internet]. Oxford University Press (OUP); 2013 Jan 17;70(3):195–283. Available from: https://doi.org/10.2146/ajhp120568

Burke JF. The effective period of preventive antibiotic action in experimental incisions and dermal lesions. Surgery. 1961 Jul 1;50(1):161-8.

Briko NI, Sidorenko SV, Protsenko DN. SCAT (Antimicrobial Therapy Control Strategy) program for inpatient care. Yakovlev SV, editor. Pero Publishing House; 2018. Available from: https://doi.org/10.17513/np.318

Clinical protocol for antibacterial prophylaxis in surgery, traumatology, obstetrics and gynecology. Available from: https://zakon.rada.gov.ua/rada/show/v0502282-08

Strachunsky LS, et al. A practical guide to anti-infective chemotherapy [Prakticheskoe rukovodstvo po antiinfekcionnoj himioterapii]. Smolensk: MakMah; 2007; 464. [In Russian]

Dobrokvashin SV, Volkov DE. Perioperative antibiotic prophylaxis in surgery [Perioperacionnaya antibiotikoprofilaktika v hirurgii]. Kazan Medical Journal; 2004; 85(5). [In Russian]

Yakovlev SV, Yakovlev VP. Cephalosporins. Consilium medicum; 2007;9(1): 20-28. [In Russian]

Dale WB, Peter MH. Antimicrobial Prophylaxis for Surgery: An Advisory Statement from the National Surgical Infection Prevention Project. Clinical Infectious Diseases [Internet]. Oxford University Press (OUP); 2004 Jun 15;38(12):1706–15. Available from: https://doi.org/10.1086/421095

Rushay AK, et al. Some features of antibiotic sensitivity of pathogens of post-traumatic osteomyelitis [Nekotorye osobennosti chuvstvitel'nosti k antibiotikam vozbuditelej posttravmaticheskogo osteomielita]. Trauma; 2009; 10(2). [In Russian]

Holovach IU. Clinical and microbiological benefits of cefoperazone / sulbactam. Hypovolemic shock in victims — pathophysiology, diagnosis, treatment [Klinichni i mikrobiolohichni perevahy tsefoperazonu/sulbaktamu. Hipovolemichnyi shok u postrazhdalykh—patofiziolohiia, diahnostyka, likuvannia]. 2012;1:37. [In Ukrainian]

Yokota T. Clinical and bacteriogoical studies on sul-bactam/cefoperazone. Sulbactam: An Advance in Overcoming Bacterial Resistance. 1986:9-16.

FU KP, NEU HC. The role of inducible β-lactamases in the antagonism seen with certain cephalosporin combinations. Journal of Antimicrobial Chemotherapy [Internet]. Oxford University Press (OUP); 1981;7(1):104–7. Available from: https://doi.org/10.1093/jac/7.1.104

Chandra A, Dhar P, Dharap S, Goel A, Gupta R, et al. Cefoperazone-Sulbactam for Treatment of Intra-Abdominal Infections: Results from a Randomized, Parallel Group Study in India. Surgical Infections [Internet]. Mary Ann Liebert Inc; 2008 Jun;9(3):367–76. Available from: https://doi.org/10.1089/sur.2007.013

Georgievsky IV. Perioperative prevention of infectious complications during surgery in the nasal cavity and paranasal sinuses [abstract]. Moscow. Moscow Medical Academy. IM Sechenov. 2010, 98-104. Available from: http://medical-diss.com/medicina/perioperatsionnaya-profilaktika-infektsionnyh-oslozhneniy-pri-hirurgicheskih-vmeshatelstvah-v-polosti-nosa-i-na-okolonoso

Lezhenko GO; Pashkova OE. Rational choice of etiotropic therapy for inflammatory diseases of the ENT organs in children [Ratsionalnyi vybir etiotropnoi terapii pry zapalnykh zakhvoriuvanniakh lor-orhaniv u ditei]. Contemporary Pediatrics, 2016, 1: 44-48. [In Ukrainian]

Castillo Z, Angeli G, Téllez D, Guercione M, Linares F, Cedeño A, Gallegos B, Henao L, Pazos I, La Rosa Z, Vincent H. Estudio multicentrico, abierto, no comparativo sobre la seguridad y eficacia de sulbactam cefoperazona en infecciones bacterianas moderadas y severas. Arch. Hosp. Vargas. 1994:177-82.

Belotserkovsky BZ, et al. Place and efficacy of cefoperazone/sulbactam in surgery and intensive care [Mesto i effektivnost' cefoperazona/sul'baktama v hirurgii i intensivnoj terapii]. Infection in surgery. 2007; 5(2):30-44. [In Russian]

Engin A, Mentes B, Turet S. Clinical-experience with sulbactam cefoperazone in critical surgical infections.

Instructions for medical storing of drug LAXERS. Available from: https://www.uf.ua/wp-content/uploads/2020/12/Instruktsiya-Laksers-ukr.pdf

Періопераційна антибіотикопрофілактика в хірургії

Published

2021-05-28

How to Cite

1.
Dmytriiev D, Nazarchuk O, Babina Y. Perioperative antibiotic prophylaxis in surgery. prmd [Internet]. 2021 May 28 [cited 2021 Aug. 3];4(1):11-7. Available from: https://perioperative.org.ua/index.php/prtmdc/article/view/54

Most read articles by the same author(s)