Experience with the use of hyaluronic acid solution (Diart) in the treatment of patients with degenerative-dystrophic diseases of the hip joint

Authors

  • P Zhuk Vinnytsia City Clinical Emergency Medical Hospital
  • M Matsipura Vinnytsia City Clinical Emergency Medical Hospital
  • V Artemenko Vinnytsia City Clinical Emergency Medical Hospital

DOI:

https://doi.org/10.31636/prmd.v7i1.3

Keywords:

joints, degenerative-dystrophic diseases, hyaluronic acid

Abstract

Background. Degenerative-dystrophic diseases of the joints are chronic progressive pathological conditions, accompanied by such features as presence of pain syndrome, impaired functional capacity, muscle weakness, deformation and instability of the joints. The high prevalence of degenerative-dystrophic diseases of the hip joint necessitates the search for optimal non-invasive treatment methods.

Objectives. This study aims to analyze the clinical results of intra-articular injections of hyaluronic acid solution (Diart) in the treatment of patients with II–III stages of degenerative-dystrophic diseases of the hip joint.

Materials and methods. The clinical results of 30 patients with II–III stages of degenerative-dystrophic diseases of the hip joint were analyzed. The group included 11 (36.67%) males and 19 (63.33%) females. The mean age of group was 61.43±7.98 years. All patients underwent a course of drug therapy using hyaluronic acid solution (Diart), which included 3 intra-articular injections of the drug, which were performed with the 7-day interval. Clinical results were evaluated at the initial visit, at 7, 14, 30 and 90 days after the first injection of Diart by objective examination of patients and analysis of subjective data using the WOMAC questionnaire. Statistical analysis was performed using Statistica 13 software package.

Results. The high effectiveness of intra-articular injections of hyaluronic acid (Diart) in the treatment of patients with II-III stages of degenerative-dystrophic diseases of the hip joint and the absence of complications associated with intra-articular injection of the drug have been established. Signs of post-injection sy- novitis, discomfort, swelling or other unpleasant sensations weren’t observed in any of the examined patients. Comparing the results established during remote period, on the 90th day of observation, and indicators determined at the initial visit, we proved a decrease in the intensity of the pain syndrome in the hip joint by 30.35%, in stiffness — by 29.57%, an improvement in the indicators characterizing the functional capacity by 21.34 % and the total values of the WOMAC index — by 27.37%, after a treatment course using Diart.

Conclusion. The high efficiency of using intra-articular injections of hyaluronic acid solution (Diart) in the treatment of patients with II–III stages of degen- erative-dystrophic diseases of the hip joint has been proven.

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References

1. Bannuru RR, Osani MC, Vaysbrot EE, Arden NK, Bennell K, Bierma-Zeinstra SMA, et al. OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis. Osteoarthritis and Cartilage [Internet]. 2019 Nov;27(11):1578–89. Available from: https://doi.org/10.1016/j.joca.2019.06.011

2. Barbara AM, Ritchie L, Severn M. Intra-Articular Hyaluronic Acid for Osteoarthritis of the Hip, Shoulder, and Ankle: Rapid Review [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2024 Mar. Available from: https://www.ncbi.nlm.nih.gov/books/NBK602915/

3. Bellamy N, Buchanan WW, Goldsmith CH, Campbell J, Stitt LW. Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. J Rheumatol. [Internet]. 1988 Dec;15(12):1833-40. Available from: https://pubmed.ncbi.nlm.nih.gov/3068365/

4. Bichsel D, Liechti FD, Schlapbach JM, Wertli MM. Cross-sectional Analysis of Recommendations for the Treatment of Hip and Knee Osteoarthritis in Clinical Guidelines. Archives of Physical Medicine and Rehabilitation [Internet]. 2022 Mar;103(3):559-569.e5. Available from: https://doi.org/10.1016/j.apmr.2021.07.801

5. Gibbs AJ, Gray B, Wallis JA, Taylor NF, Kemp JL, Hunter DJ, et al. Recommendations for the management of hip and knee osteoarthritis: A systematic review of clinical practice guidelines. Osteoarthritis and Cartilage [Internet]. 2023 Oct;31(10):1280–92. Available from: https://doi.org/10.1016/j.joca.2023.05.015

6. Nouri F, Babaee M, Peydayesh P, Esmaily H, Raeissadat SA. Comparison between the effects of ultrasound guided intra-articular injections of platelet-rich plasma (PRP), high molecular weight hyaluronic acid, and their combination in hip osteoarthritis: a randomized clinical trial. BMC Musculoskeletal Disorders [Internet]. 2022 Sep 12;23(1):856. Available from: https://doi.org/10.1186/s12891-022-05787-8

7. Rees HW. Management of Osteoarthritis of the Hip. Journal of the American Academy of Orthopaedic Surgeons [Internet]. 2020 Apr 1;28(7):e288–91. Available from: https://doi.org/10.5435/jaaos-d-19-00416

8. Nanda A, Janga LSN, Hamid P. Comparing Intra-articular Platelet-Rich Plasma With Hyaluronic Acid for the Treatment of Hip Osteoarthritis: A Systematic Review and Meta-Analysis. Cureus. [Internet]. 2023 Oct 29;15(10):e47919. Available from: https://doi.org/10.7759/cureus.47919

9. Sinatti P, Sánchez Romero EA, Martínez-Pozas O, Villafañe JH. Effects of Patient Education on Pain and Function and Its Impact on Conservative Treatment in Elderly Patients with Pain Related to Hip and Knee Osteoarthritis: A Systematic Review. Int J Environ Res Public Health [Internet]. 2022 May 19;19(10):6194. Available from: https://doi.org/10.3390/ijerph19106194

10. van Doormaal MCM, Meerhoff GA, Vliet Vlieland TPM, Peter WF. A clinical practice guideline for physical therapy in patients with hip or knee osteoarthritis. Musculoskeletal Care [Internet]. 2020 Dec;18(4):575-595. Available from: https://doi.org/10.1002/msc.1492

11. Zampogna B, Papalia R, Papalia GF, Campi S, Vasta S, Vorini F, Fossati C, Torre G, Denaro V. The Role of Physical Activity as Conservative Treatment for Hip and Knee Osteoarthritis in Older People: A Systematic Review and Meta-Analysis. J Clin Med. [Internet]. 2020 Apr 18;9(4):1167. Available from: https://doi.org/10.3390/jcm9041167

Досвід використання розчину гіалуронової кислоти (Diart) в лікуванні пацієнтів з дегенеративно-дистрофічними захворюваннями кульшового суглоба

Published

2024-09-04

Issue

Section

Original article

How to Cite

1.
Experience with the use of hyaluronic acid solution (Diart) in the treatment of patients with degenerative-dystrophic diseases of the hip joint. prmd [Internet]. 2024 Sep. 4 [cited 2026 Jul. 6];7(1):17-23. Available from: https://perioperative.org.ua/index.php/prtmdc/article/view/122