High-dose N-acetylcysteine therapy in the treatment of pneumonia


  • Dmytro Dmytriiev National Pirogov Memorial Medical University, Vinnytsia
  • Oleksandr Nazarchuk National Pirogov Memorial Medical University, Vinnytsia
  • Yuliana Babina National Pirogov Memorial Medical University, Vinnytsia




COVID-19, N-acetylcysteine, pneumonia


The article presents modern data on the use of N-acetylcysteine in the treatment of infectious diseases of the respiratory tract in the practice of a physician. Its antioxidant, mucolytic, anti-inflammatory, pulmoprotective and antitoxic properties are described. The emphasis is placed on the antioxidant properties of N-acetylcysteine, which are expressed when used in high doses of 1200 mg/day or more. There is a review of the literature on the use of high doses of N-acetylcysteine in the treatment of pneumonia, cystic fibrosis, COPD, ARDS. The effect of N-acetylcysteine on individual risk factors for prolonged pneumonia is analyzed. Given the epidemiological situation around the world, the antioxidant properties of N-acetylcysteine in the treatment of pneumonia, including complicated COVID-19, are relevant and require further study.


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Високодозова терапія N-ацетилцистеїном у лікуванні  пневмонії



How to Cite

Dmytriiev D, Nazarchuk O, Babina Y. High-dose N-acetylcysteine therapy in the treatment of pneumonia. prmd [Internet]. 2021 May 20 [cited 2023 Mar. 30];4(1):4-10. Available from: https://perioperative.org.ua/index.php/prtmdc/article/view/53