Principles of using esmolol in the practice of anesthesiologists and intensive care physicians


  • Volodymyr Chernii



anesthesiology and intensive care, selective beta-1-blocker esmolol


Prevention and reduction of cardiac risk remains an important issue in anesthesiology and intensive care. There is a successful clinical experience in the use of esmolol for the correction of hemodynamic and ischemic disorders in acute coronary syndrome, in the perioperative period with excessive activation of the sympathoadrenal system. A large number of works are devoted to the use of esmolol as a drug that prevents hemodynamic changes due to tracheal intubation. The aim of the study was to evaluate the use of esmolol and dexmedetomidine as intravenous adjuvants in general analgesia during thyroidectomy in patients with thyrotoxicosis. The use of esmolol (Biblock) and dexmedetomidine in anesthesia for thyroidectomy, suppresses the hemodynamic response caused by surgical stress. Both adjuvants stabilize oxygen consumption and maintain a stable metabolism. Both drugs are quite effective as intravenous adjuvants in general analgesia for thyroidectomy in patients with thyrotoxicosis. They are the drugs of choice and can be recommended in practical anesthesiology.


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Nikonov VV, Sokolov AS, Kinoshenko VI. Possibilities of using cardioselective parenteral beta-blockers in emergency medicine [Vozmozhnosti primeneniya kardioselektivnyh parenteral'nyh beta-blokatorov v medicine neotlozhnyh sostoyanij]. Emergency medicine. 2018;1(88). [In Russian]

Maurovich-Horvat P, Károlyi M, Horváth T, Szilveszter B, Bartykowszki A, Jermendy ÁL, et al. Esmolol is noninferior to metoprolol in achieving a target heart rate of 65 beats/min in patients referred to coronary CT angiography: A randomized controlled clinical trial. Journal of Cardiovascular Computed Tomography [Internet]. Elsevier BV; 2015 Mar;9(2):139–45. Available from:

Marx J, Hockberger R, Walls R. Rosen's Emergency Medicine-Concepts and Clinical Practice E-Book: 2-Volume Set. Elsevier Health Sciences; 2013 Aug 1.

Kirchhof P, Benussi S, Kotecha D, Ahlsson A, Atar D, Casadei B, Castella M, Diener HC, Heidbuchel H, Hendriks J, Hindricks G. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. European journal of cardio-thoracic surgery. 2016 Nov 1;50(5):e1-88.

European Heart Rhythm Association (EHRA)/European Association of Cardiovascular Prevention and Rehabilitation (EACPR) position paper on how to prevent atrial fibrillation endorsed by the Heart Rhythm Society (HRS) and Asia Pacific Heart Rhythm Society (APHRS). Europace [Internet]. Oxford University Press (OUP); 2016 Nov 4;euw242. Available from:

January CT, Wann LS, Alpert JS, Calkins H, Cigarroa JE, Cleveland JC, Conti JB, Ellinor PT, Ezekowitz MD, Field ME, Murray KT. 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the Heart Rhythm Society. Journal of the American College of Cardiology. 2014 Dec 2;64(21):2246-80.

Efe EM, Bilgin BA, Alanoglu Z, Akbaba M, Denker C. Comparison of bolus and continuous infusion of esmolol on hemodynamic response to laryngoscopy, endotracheal intubation and sternotomy in coronary artery bypass graft. Brazilian Journal of Anesthesiology (English Edition) [Internet]. Elsevier BV; 2014 Jul;64(4):247–52. Available from:

Frendl G, Sodickson AC, Chung MK, Waldo AL, Gersh BJ, Tisdale JE, et al. 2014 AATS guidelines for the prevention and management of perioperative atrial fibrillation and flutter for thoracic surgical procedures. The Journal of Thoracic and Cardiovascular Surgery [Internet]. Elsevier BV; 2014 Sep;148(3):e153–e193. Available from:

Marx J, Hockberger R, Walls R. Rosen's Emergency Medicine-Concepts and Clinical Practice E-Book: 2-Volume Set. Elsevier Health Sciences; 2013 Aug 1.

Trekova NA, Axelrod BA, Tolstova IA, Guleshov VA, Poplavsky IV, Guskov DA. Efficiency and controllability of adrenergic blockade with esmolol (breviblok) in operations on the heart and aorta [Effektivnost' i upravlyaemost' adrenergicheskoj blokady esmololom (breviblok) pri operaciyah na serdce i aorte]. Anesthesiology and Reanimatology. 2012; 2. [In Russian]

Lee SJ, Lee JN. The effect of perioperative esmolol infusion on the postoperative nausea, vomiting and pain after laparoscopic appendectomy. Korean Journal of Anesthesiology [Internet]. The Korean Society of Anesthesiologists; 2010;59(3):179. Available from:

Harless M, Depp C, Collins S, Hewer I. Role of Esmolol in Perioperative Analgesia and Anesthesia: A Literature Review. AANA journal. 2015 Jun 1;83(3):167-77.

Kobelyatskiy YuYu, Yovenko IA. The use of esmolol in anesthesiology: current trends and our own experience [Ispol'zovanie esmolola v anesteziologii: sovremennye tendencii i sobstvennyj opyt]. Emergency medicine. 2010; 1(26). [In Russian]

Cherniy VI, Denysenko AI. CURRENT POSSIBILITIES OF USE OF INDIRECT CALORIMETRY IN PERIOPERATIVE ENERGY MONITORING. Клінічна та профілактична медицина [Internet]. State Institution of Science Research and Practical Center; 2020 May 28;2(12):79–89. Available from:

Watts R, Thiruvenkatarajan V, Calvert M, Newcombe G, van Wijk R. The effect of perioperative esmolol on early postoperative pain: A systematic review and meta-analysis. Journal of Anaesthesiology Clinical Pharmacology [Internet]. Medknow; 2017;33(1):28. Available from:

European Heart Rhythm Association (EHRA) consensus document on the management of supraventricular arrhythmias, endorsed by Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS), and Sociedad Latinoamericana de Estimulación Cardiaca y Electrofisiologia (SOLAECE). EP Europace [Internet]. Oxford University Press (OUP); 2017 Feb 14;19(4):659–659. Available from:

Принципы использования эсмолола в практике анестезиолога и врача-интенсивиста



How to Cite

Chernii V. Principles of using esmolol in the practice of anesthesiologists and intensive care physicians. prmd [Internet]. 2021 May 22 [cited 2022 Aug. 11];4(1):22-8. Available from:



Original article