Treatment of widespread infected wounds of different etiology


  • Olha Kovalenko Bogomolets National Medical University, Kyiv, Ukraine
  • Oksana Osadcha DU “Institute of Hematology and Transfusiology of the NAMS of Ukraine”
  • Anton Kovalenko DU “Institute of Hematology and Transfusiology of the NAMS of Ukraine”
  • Vitalii Nazarenko Kyiv city hospital № 2, Kyiv, Ukraine



widespread infected wounds, decasan, intoxication syndrome, detoxication therapy, reosorbylact infusion, braxone (tobramycin), leflocin 750


Background. The infections problem of the surgical departments is increasing due to resistance of pathogens to antibiotics, so it becomes an important issue to develop new regimens for the treatment of common infected wounds.

The aim of the study was expanding the possibility of treating infected wounds with the use of infusion therapy with reosorbylact, decasan antiseptic, and braxone and leflocin antibiotics.

Materials and Methods. 55 patients with infected wounds of different etiology were included in the study. The mean patients age was 43.4 ± 4.7 years. Decasan antiseptic used in the treatment of infected wounds in patients of the main group, the antibiotics braxon (tobramycin) and leflocin 750 (levofloxacinum) is intended simultaneously for empirical antibiotic therapy, reosorbylact solution is included in the infusion therapy.

Results. Intoxication syndrome was observed in patients with widespread infected wounds. The initial level of urea blood exceeded 1.6–1.7 times after the patient admission. Creatinine level decreased by 23 % from baseline for 5–7 days of treatment, in patients of the main group during infusion detoxication therapy with Reosorbylact, it remained raised to 9–11 days in patients of the comparison group. Leukocytosis, TGN, and LII decreased in case of empirical antibacterial therapy with braxone (tobramycin) and leflосin 750. The number of microbial associations decreased to 1.6 ± 0.3 using decasan for wound treatment up to 9 days. Bacterial contamination of wounds decreased to a level suitable for effective auto graft (<104 per 1 g of tissue).

Conclusions. The complex program of treatment for patients with infected wounds contributed to the reduction of intoxication syndrome, faster reduction of the number of microorganisms in the wound, preparation of wounds for skin graft, shortening the treatment time by 4.3 days.


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Shapryns'kyj VO, Skal's'kyj SS, Palamarchuk SV, Shapryns'kyj YeV. Suchasni pidkhody do likuvannia hnijnykh ran. Nevyrisheni Problemy [Modern approaches to the treatment of purulent wounds. Unresolved Problems]. Shpytal'na khirurhiya. Journal of the name of L. Y. Kovalchuk; 2015; 3:70–73. [In Ukrainian]. Available from:

Dacenko BM, Percev IM, Tamm TI, Belov SG, Chefranov AV, Dacenko A. B et al. Mestnaja profilaktika nagnoenija ran i principy ih lechenija v faze gnojnogo vospalenija [Local prevention of suppuration of wounds and principles of their treatment in purulent inflammation phase]. Problemi vіjs'kovoї ohoroni zdorov'ja. 2012; 34(2):248–255. [In Russian]. Available from:

Volkov AO. Mikroflora gnijnih ran ta suchasni pidhodi do vikoristannya antiseptikiv v hirurgichnij praktici [Mіcroflora of purulent wounds and modern approaches to antiseptics’ use in surgical practice]. Annals of Mechnikov Institute; 2009; 2:19–23. [In Ukrainian].

Sartelli M, Guirao X, Hardcastle TC, Kluger Y, Boermeester MA, Raa K et al. 2018 WSES/SIS-E consensus conference: recommendations for the management of skin and soft-tissue infections. World Journal of Emergency Surgery [Internet]. Springer Science and Business Media LLC; 2018 Dec; 13(1). Available from:–018–0219–9

Nazarchuk OA. Suchasni aspekty doslidzhennia i vykorystannia antyseptykiv v medytsyni [Modern aspects of the research and usage of antiseptics in medicine]. Biomedical and biosocial anthropology. 2014; 23:29–35. [In Ukrainian].

Seifi B, Sahbaei F, Zare M, Abdoli A, Heidari and. A Comparative Study Between Povidone-iodine and Manugel 85 on Surgical Scrub. Materia Socio Medica [Internet]. ScopeMed International Medical Journal Management and Indexing System; 2016; 28(5):348. Available from:–352

Luo Y, Kawashima A, Ishido Y, Yoshihara A, Oda K, Hiroi N et al. Iodine Excess as an Environmental Risk Factor for Autoimmune Thyroid Disease. International Journal of Molecular Sciences [Internet]. MDPI AG; 2014 Jul 21; 15(7):12895–912. Available from:

Nahajchuk VІ, Nazarchuk OA, Palij IH et al. Kharakterystyka suchasnykh infektsijnykh uskladnen' u khvorykh z opikamy [To characteristics of modern infectious complications in patients with burn]. Ukrains'kyj medychnyj zhurnal; 2014; 5(103):123–126. [in Ukrainian].

Negut I, Grumezescu V, Grumezescu A. Treatment Strategies for Infected Wounds. Molecules [Internet]. MDPI AG; 2018 Sep 18; 23(9):2392. Available from:

Tewarie L, Chernigov N, Goetzenich A, Moza A, Autschbach R, Zayat R. The Effect of Ultrasound-Assisted Debridement Combined with Vacuum Pump Therapy in Deep Sternal Wound Infections. Annals of Thoracic and Cardiovascular Surgery [Internet]. Editorial Committee of Annals of Thoracic and Cardiovascular Surgery; 2018; 24(3):139–46. Available from:–00244

Vil'tsaniuk OA. Efektyvnist’ zastosuvannia mazej “Oflokain Darnytsia” ta “Metyluratsyl iz miramistynom” v kompleksnomu likuvanni hnijno-zapal'nykh zakhvoriuvan' m'iakykh tkanyn [Efficiency of the use of ointments. oflocain. darnitsa and methyluracil with myramistin. in complex treatment of purulent and inflammatory diseases of soft tissues ]. Shpytal’na khirurhiya; 2011; 4:56–59. [In Ukrainian].

Vozniuk VV. Otsinka endotoksykozu pry riznykh patolohichnykh stanakh [Evaluation of endotoxicosis in various pathological conditions Journal of the practitioner]. Zhurnal praktychnoho likaria; 2006; 4:27–39. [In Ukrainian].

Chernyj VY, Kolesnykov AN, Olejnykov KN, Ehorov AA, Byloshapka VY. Ratsyonal'naia ynfuzyonnaia terapyia [Rational infusion therapy]. Izdatel' Zaslavskyj AYu; 2012:188 р. [In Russian].

Ivashchenko AV. Reosorbylakt v kompleksnom lechenyy fenomena “zastyvshej rany” u bol'nykh s dyabetycheskoj stopoj [Reosorbilact in the complex treatment of the phenomenon of "frozen wounds" in patients with diabetic foot]. Ukrains'kyj khimioterapevtychnyj zhurnal; 2012; 3(26):75–77. [In Russian]. Available from:

Nazarchuk OA, Nahajchuk VI. Otsinka efektyvnosti zastosuvannia dekasanu, dekametoksynu ta joho kompozytsii u patsiientiv z vazhkoiu termichnoiu travmoiu [Evaluation of the effectiveness of the use of decasan, decamethoxin and its composition in patients with severe thermal trauma] Annals of Mechnikov Institute; 2015; 2:184–190. [In Ukrainian].

Treatment of widespread infected wounds of different etiology



How to Cite

Kovalenko O, Osadcha O, Kovalenko A, Nazarenko V. Treatment of widespread infected wounds of different etiology. prmd [Internet]. 2019Nov.1 [cited 2020Nov.25];2(2):31-7. Available from:



Original article